Where Lasting Itch Relief Begins
Befrena is a fast-acting injection, administered at your veterinarian’s office—providing allergic itch relief that helps best friends get back to what they do best.
Help Your Bestie Feel Their Best
Allergic itch can cause discomfort for your dog and stress for you as an owner. Befrena works quickly to help bring your bestie long-lasting relief.
Before Befrena
Allergic itch triggers discomfort that leads to licking, chewing, and scratching behaviors and an unhappy furry friend.1,2
After Befrena Treatment
Fast-acting Befrena brings relief within 24 hours of the initial dose.
Maintenance Dosing
Visit your dog’s veterinary clinic once every 6-8 weeks or as needed to maintain relief and minimize clinical signs.
How Befrena Works
Stop the itch signal where it starts
Working in a similar way to the dog's immune system, Befrena targets and neutralizes IL-31, a specific protein involved in sending itch signals to the brain.
Give Them Fast-Acting, Long-Lasting Relief
Long-LastingBefrena provides at least 6 weeks of itch relief
Fast-ActingBefrena starts relieving itch in 24 hours.
ConvenientInjections administered in-clinic means no need for at-home daily treatment.
SafeThere is no age or weight restriction for Befrena.
Understanding Allergic Itch
Why is my dog itching?
Canine allergic skin disease (atopic dermatitis) is a widespread condition that triggers itching in dogs.
Causes range from food and fleas to environmental allergens.1,2 Left untreated, these behaviors can damage your dog’s skin—putting them at greater risk for infections leading to hot spots and increased inflammation.1,2
Finding Relief
Track the Itch; Start the Conversation
Give your bestie fast-acting, long-lasting relief from allergic itch. Talk to your vet today about Befrena with the help of our downloadable brochure and Itch Tracker. Help bridge the gap between home and the clinic by providing your vet a precise look at your dog's comfort levels so you can work together on a treatment plan that works.
Frequently Asked Questions About Befrena
Always read, understand, and follow the label and use directions.
INDICATIONS: Befrena has been shown to be effective for the treatment of dogs against allergic dermatitis and canine atopic dermatitis (CAD).
For product questions or to report suspected adverse events, call 1-888-545-5973.
1. Collins B. Atopic Dermatitis. Cornell Richard P. Riney Canine Health Center. https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/canine-health-topics/atopic-dermatitis-atopy. Accessed January 15, 2026.
2. Llera R, Hunter T, Ward E. Pruritus: Itching and Scratching in Dogs. VCA Animal Hospitals. https://vcahospitals.com/know-your-pet/pruritus-itching-and-scratching-in-dogs. Accessed January 15, 2026.
3. Elanco Animal Health. Data on File. REF-28722
