Credelio® (lotilaner)

Credelio tablets are made with a beef flavoring containing pork liver and soy but no actual beef.⁷ Tablets also contain barley, wheat and lactose.^7,8 Consult your veterinarian before using in dogs with food allergies to pork, soy, barley, wheat or lactose.

Lotilaner is a member of the isoxazoline class of parasiticides. It has acaricidal and insecticidal activity, and acts as an inhibitor of gamma-aminobutyric acid (GABA)–gated chloride channels (GABACls).⁴

Please reference the individual packaging of Credelio for the expiration date.

No stability testing has been performed on tablets once they have been removed from the blister pack. We do not recommend taking the tablets out of the blister pack for storage in another container. 

Credelio tablets should only be taken out of the blister pack at the time of dosing.

According to the label, Credelio tablets must be stored at 59-77°F (15-25°C). Temporary periods of time outside of this range, 41-104°F (5-40°C), are permitted.

Yes, Credelio is considered gluten-free.^{7, 9, 11}

Credelio can be used as part of a treatment strategy for the control of FAD. In the U.S. field study, dogs in the Credelio treatment group with signs of FAD showed an improvement in clinical signs associated with FAD as a direct result of eliminating fleas.

Credelio is an oral medication that circulates in a dog’s bloodstream. Specific bathing studies have not been conducted, but because Credelio is a systemic medication and not applied topically, bathing would not be expected to have any effect on the efficacy. Credelio, unlike topical products, offers dog owners a convenient way to administer flea and tick control that won’t interfere with medically required or other frequent bathing.

Credelio kills adult fleas quickly and effectively when used monthly according to the label directions. Remember that all animals in the household should be treated with an approved flea product to minimize the likelihood of flea re-infestation.

Regardless of the product used to kill the fleas, a dog can continue to be exposed to the fleas that live in the environment. If these fleas jump onto a dog and feed, they will be killed by Credelio.

Any fleas seen on a dog within a month after the dog has received Credelio are likely from the environment. These "new" fleas will be killed quickly and effectively.

Credelio is a systemic medication, meaning that ticks have to bite a dog to be exposed to Credelio and for Credelio to start to work. It could be that the ticks you are seeing are those that have just recently crawled onto the dog and have not yet started to feed (and, therefore, have not yet been exposed to Credelio).

Dead ticks may remain attached to a dog. Before starting its blood meal, a tick may securely attach to a pet’s skin by secreting an adhesive compound into the bite wound or by anchoring its longer hypostome (mouthparts).¹² On a treated dog, dead ticks might passively remain anchored and can easily be removed.

If a dose is missed, administer Credelio with food and resume a monthly dosing schedule to minimize the opportunity for tick and flea re-infestations. Consult your veterinarian about any concerns you may have about ticks and fleas due to the late/missed dose.

Credelio must be administered with food or given within 30 minutes of feeding. Feeding ensures your dog achieves peak blood levels and exposure, which is necessary for initial and ongoing efficacy.

Credelio has a rapid onset of action and starts to kill fleas in just four hours. In a well-controlled U.S. laboratory study, Credelio demonstrated 100% effectiveness against adult fleas within 12 hours after administration, up to day 35.

Credelio acts to kill adult fleas and, in a speed-of-kill study, Credelio killed 100% of fleas on dogs within 12 hours of administration, up to day 35.² Adult female fleas begin to lay eggs within 20-24 hours of taking her first blood meal.13 Since Credelio works fast,* killing 100% of fleas within 12 hours for the entire month, Credelio kills fleas before they can lay eggs.

*Credelio starts killing fleas in four hours and kills 99% within eight hours for 35 days. Credelio is greater than 97% effective against labeled tick species 48 hours after administration or infestation for 30 days. In a controlled European study, Credelio starts killing ticks (𝘐𝘹𝘰𝘥𝘦𝘴 𝘳𝘪𝘤𝘪𝘯𝘶𝘴) in four hours.

Yes. Credelio is a systemic medication, which means that ticks/fleas have to feed in order to be exposed to lotilaner, the active ingredient.

The safety of Credelio in breeding dogs has not been established.

Dogs and puppies from 2 months of age to 16 years of age were treated with Credelio in a U.S. clinical field trial. The youngest dogs in our margin-of-safety studies were 8 weeks old.¹⁰

There are no known contraindications for the use of Credelio.

Credelio is an oral flea and tick medication for dogs in small, chewable tablets that are formulated to provide a minimum dose of 9 mg/lb (20 mg/kg) of lotilaner.

Credelio chewable tablets are formulated to provide a minimum dose of 9 mg/lb (20 mg/kg) of lotilaner. Your veterinarian may elect to prescribe a combination of tablets to provide your dog’s effective dose in certain circumstances. Please discuss any questions regarding dosing with your veterinarian. Elanco Animal Health does not recommend dosing outside of the labeled recommendations.

Puppies should be at least 8 weeks old and weigh 4.4 pounds or more. Puppies should be weighed each month and dosed accordingly at the time of administration with a minimum dosage of 9 mg/lb or 20 mg/kg.

Elanco does not recommend splitting Credelio tablets because they are not scored for splitting. A variety of tablet sizes is available to allow for accurate dosing according to a dog’s weight.

Credelio is available as a chewable tablet. The tablets can be chewed or swallowed whole.

Credelio must be administered with food or given within 30 minutes after feeding. While we did not conduct any studies where a crushed Credelio tablet was added to food or water and fed to a dog, Credelio is a chewable tablet that can be chewed or swallowed whole.