K9 Advantix® II flea, tick and mosquito prevention for dogs

For over 20 years, dog owners have trusted the K9 Advantix® brand to kill and repel fleas, ticks and mosquitoes too. With one easy-to-apply topical treatment, K9 Advantix® II works all month to kill pests through contact so they don’t have to bite your pet to die. Just select your dog’s weight, your preferred dosage and your favorite retailer below to buy now.

Why choose K9 Advantix® II flea, tick and mosquito treatment?

  • An icon of a flea, tick, and mosquito
    Quickly kills and repels

    Starts to kill fleas, ticks and mosquitoes within 12 hours — half the time of other leading brands.

  • An icon of a vet cross with a paw print in the center
    Vet recommended

    No prescription needed. Effective on dogs and puppies 7 weeks of age and older that weigh 4 or more pounds.

  • An icon of an applicator
    Easy to apply

    Goes on in seconds. Apply drops directly on your dog's skin — no hard-to-swallow pills. 

  • An icon of a water drop within a shield
    30 days of waterproof protection

    K9 Advantix® II becomes waterproof after 24 hours and stays that way all month long.

Ready to give your dog flea, tick and mosquito prevention with K9 Advantix® II?

See how K9 Advantix® II for dogs stacks up to the competition.

Compare K9 Advantix II® vs. Frontline® Plus, PetArmor®, NexGard® and Bravecto®.

K9 Advantix II

Based on label claims. 

Do not use K9 Advantix® II on cats.

K9 Advantix® II comes in different dosage sizes and package quantities. Get it for your dog or puppy today.

How to apply K9 Advantix® II for dogs 

It's easy to learn how to apply K9 Advantix® II to your dog. Simply watch this video, follow the steps below or refer to your product package instructions. Be sure to apply it while indoors.

K9 Advantix® II directions for application


Hold applicator tube in an upright position. Pull cap off tube.


Turn the cap over and push the other end of the cap onto the tip of the tube. Twist the cap to break the seal, and then remove the cap from the tube.


Evenly apply the entire contents of the tube along the top of the dog’s back, from the shoulder down to the base of the tail. The number of spots depends on the size and weight of your dog (please refer to the product label).


At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze a portion of the solution on the skin.

Do not use K9 Advantix® II on cats.

K9 Advantix, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

Frontline and NexGard are registered trademarks of Boehringer Ingelheim Animal Health. Bravecto is a registered trademark of Intervet, Inc. dba Merck Animal Health. PetArmor is a registered trademark of Velcera, Inc.