Advantage® XD for cats (spinetoram)

Say goodbye to monthly flea treatments. Advantage® XD for kittens and cats provides two months of flea protection in a single application with our exclusive, naturally derived active ingredient, spinetoram.

To buy Advantage® XD, just select your cat’s weight, your preferred dosage and your favorite retailer below — no prescription required.

Introducing two months of flea protection in one dose

  • A calendar icon indicating two times more protection than other monthly flea treatment for cats
    Lasts 2x longer than monthly topicals†

    Advantage® XD (spinetoram) kills fleas for two months with one dose, outlasting the typical six-week flea life cycle — and the monthly competition.

  • A time icon for fast-acting flea protection for cats and kittens
    Fast acting

    Advantage® XD (spinetoram) starts killing fleas in as little as 30 minutes.* Some other topical treatments take as long as 24 hours to start working.

  • An icon of active ingredient in advantage xd flea treatment
    Sourced from nature

    Spinetoram, our exclusive active ingredient in Advantage® XD for cats, is derived from soil microbes that were found to be effective against fleas.

  • An icon of no flea pills or prescription for cats needed
    No pill or prescription required

    Unlike oral treatments, easy-to-apply Advantage® XD (spinetoram) kills fleas through contact so they don’t have to bite your cat to die.

*Starts killing fleas in 30 minutes to 4 hours.
Based on label claims.

Spinetoram: A naturally derived ingredient 

Wondering how to get rid of fleas on cats naturally? While natural flea treatments for cats exist, many simply aren’t effective. The best way to get rid of fleas is to use a tested and proven preventive like Advantage® XD. Our exclusive active ingredient in Advantage® XD, spinetoram, is sourced from flea-fighting soil microbes and has received a Green Chemistry Challenge Award.1 Each tube of fragrance-free Advantage® XD contains just 15% spinetoram, while the remaining 85% is liquids that help the product spread over your cat’s skin to kill fleas for two months with one dose.

See the product label >

Ready to get two months of flea protection in one dose with Advantage® XD (spinetoram)?

Flea protection for cats that outlasts the competition

How to choose and use Advantage® XD (spinetoram)

A video thumbnail with overlay text apply advantage XD in 4 steps

How do I apply Advantage® XD for cats?

It’s easy to apply Advantage® XD to your cat. To open the tube, just twist the nozzle a quarter turn to break the seal. Then, part your cat’s hair at the base of the head and squeeze the entire contents of the tube directly onto your cat’s skin. That’s it! Remember, you only need to use a single application tube every two months.

A woman looking at her tabby cat with an icon that reads extended duration each dose lasts 2 months

How does Advantage® XD get rid of fleas for two months?

Indoor and outdoor cats alike can get fleas, and a single flea can lay up to 50 eggs in one day. Advantage® XD starts working in as little as 30 minutes to 4 hours and kills adult fleas through contact before they have a chance to lay eggs. One treatment remains effective for two months, outlasting the typical six-week flea life cycle.

Advantage® XD flea protection for small and large cat packs with a no-prescription icon and a two-month-treatment icon

Which size of Advantage® XD is right for my cat?

Advantage® XD is available in one-packs (two months of protection) and two-packs (four months of protection).

Small cat: 8 weeks and older and weighing between 1.8 and 9 pounds
Large cat: 8 weeks and older and weighing more than 9 pounds

Top questions about Advantage® XD for cats (spinetoram)

Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other product names are trademarks of their respective owners.

Always read, understand and follow the label and use directions.