Advantage® XD for cats (spinetoram)

Say goodbye to monthly flea treatments. Advantage^® XD for kittens and cats provides two months of flea protection in a single application with our exclusive, naturally derived active ingredient, spinetoram.

To buy Advantage^® XD, just select your cat’s weight, your preferred dosage and your favorite retailer below — no prescription required.

Product Label

Product collection of Advantage™ XD for small cat and large cat with two-months duration icon and flea icon

Introducing two months of flea protection in one dose

Lasts 2x longer than monthly topicals†
Advantage^® XD (spinetoram) kills fleas for two months with one dose, outlasting the typical six-week flea life cycle — and the monthly competition.
Fast acting
Advantage^® XD (spinetoram) starts killing fleas in as little as 30 minutes.* Some other topical treatments take as long as 24 hours to start working.^†
Sourced from nature
Spinetoram, our exclusive active ingredient in Advantage^® XD for cats, is derived from soil microbes that were found to be effective against fleas.
No pill or prescription required
Unlike oral treatments, easy-to-apply Advantage^® XD (spinetoram) kills fleas through contact so they don’t have to bite your cat to die.

*Starts killing fleas in 30 minutes to 4 hours.
^†Based on label claims.

Advantage™ XD applicator with 15 percent spinetoram active ingredient text

Spinetoram: A naturally derived ingredient

Wondering how to get rid of fleas on cats naturally? While natural flea treatments for cats exist, many simply aren’t effective. The best way to get rid of fleas is to use a tested and proven preventive like Advantage^® XD. Our exclusive active ingredient in Advantage^® XD, spinetoram, is sourced from flea-fighting soil microbes and has received a Green Chemistry Challenge Award.¹ Each tube of fragrance-free Advantage^® XD contains just 15% spinetoram, while the remaining 85% is liquids that help the product spread over your cat’s skin to kill fleas for two months with one dose.

See the product label >

Ready to get two months of flea protection in one dose with Advantage^® XD (spinetoram)?

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Flea protection for cats that outlasts the competition^†

How to choose and use Advantage^® XD (spinetoram)

A video thumbnail with overlay text apply advantage XD in 4 steps

How do I apply Advantage® XD for cats?

It’s easy to apply Advantage^® XD to your cat. To open the tube, just twist the nozzle a quarter turn to break the seal. Then, part your cat’s hair at the base of the head and squeeze the entire contents of the tube directly onto your cat’s skin. That’s it! Remember, you only need to use a single application tube every two months.

WATCH THE VIDEO

A woman looking at her tabby cat with an icon that reads extended duration each dose lasts 2 months

How does Advantage® XD get rid of fleas for two months?

Indoor and outdoor cats alike can get fleas, and a single flea can lay up to 50 eggs in one day. Advantage^® XD starts working in as little as 30 minutes to 4 hours and kills adult fleas through contact before they have a chance to lay eggs. One treatment remains effective for two months, outlasting the typical six-week flea life cycle.

MORE ABOUT THE FLEA LIFE CYCLE

Advantage® XD flea protection for small and large cat packs with a no-prescription icon and a two-month-treatment icon

Which size of Advantage® XD is right for my cat?

Advantage^® XD is available in one-packs (two months of protection) and two-packs (four months of protection).

Small cat: 8 weeks and older and weighing between 1.8 and 9 pounds
Large cat: 8 weeks and older and weighing more than 9 pounds

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Top questions about Advantage^® XD for cats (spinetoram)

: Do not have contact or allow children to have contact with the area treated with Advantage™ XD for cats until completely dry. See product label for more information.
: Advantage™ XD for cats starts killing fleas in 30 minutes to 4 hours. See product label for more information.
: There is no expiration date required on the packaging by the EPA for Advantage™ XD for cats. We recommend the product should be kept in its original packaging and stored as directed on the product label.
: You can use Advantage™ XD for cats on kittens or cats 8 weeks of age and older and weighing 1.8 pounds or more. See product label for more information.
: Applying Advantage™ XD for the prevention and treatment of fleas to your feline friend is easy and convenient. Before applying, check the weight range and minimum age on the package to choose the appropriate product for your cat.

How to apply Advantage™ XD for cats:

Remove one applicator tube from the tray and hold applicator tube in an upright position.

Open applicator tube by twisting the nozzle tip.

Part the hair on the neck at the base of the head until the skin is visible. Place the tip of the tube directly above the skin and squeeze the tube 2-4 times to expel the contents of the tube directly on the skin. For best results, apply at the base of the head, not between shoulder blades. Avoid getting the product in your cat’s eyes or mouth. Treatment at the base of the head will minimize the opportunity for the cat to directly lick the product.

Discard empty applicator tube in the trash.

For more detailed instructions, watch our application video.
: Advantage™ XD topical solution is labeled for the prevention and treatment of flea infestations. It kills fleas through contact, so fleas do not have to bite your cat to die. With oral flea medications, fleas have to bite your cat and ingest the medication before they are killed.
: Advantage XD™ for cats and Advantage® II for cats contain different active ingredients, kill fleas in different ways and have different treatment frequencies. Advantage™ XD offers two months of prevention and treatment of fleas in a single application and Advantage® II offers one month of prevention and treatment of fleas in a single application.
: No, they are different products with different active ingredients.
: Spinetoram, the active ingredient in Advantage™ XD for cats, was developed from soil microbes that were found to be effective against fleas and has received a Green Chemistry Challenge Award¹. Potential side effects of Advantage™ XD include application site reactions such as hair loss; greasy, clumping or matting hair; or redness, inflammation and itching. Other side effects such as inactivity, vomiting and lack of appetite have also been reported. If these or any other side effects occur, consult your veterinarian, your cat’s healthcare expert. For technical assistance or to report a side effect, call Elanco at 888-545-5973. See product label for more information.
: Advantage™ XD for cats contains an exclusive active ingredient called spinetoram. The primary target of action of spinetoram on insects is an activation of nicotinic acetylcholine receptors [nAChRs]. Some action is also provided by spinosyns binding to GABA receptors. This overall effect leads to involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinetoram-induced hyperexcitation results in prostration and paralysis resulting in death of fleas.¹See product label for more information.

¹Paarlberg, Tandy et al. 2017. “Effectiveness and residual speed of flea kill of a novel spot on formulation of spinetoram (Chersitin) for cats.” Parasites & Vectors, 10:59.
: No, you cannot split tubes of Advantage™ XD for cats between multiple cats. To successfully prevent and treat fleas, cats must be treated with their own dose of Advantage™ XD. Follow label directions for application. Off-label use of EPA products is a violation of federal law and cannot be recommended by Elanco. See product label for more information.
: No, do not use Advantage™ XD for cats on dogs. Please follow label directions for the application of our flea products. Off-label use of EPA products is a violation of federal law and cannot be recommended by Elanco. See product label for more information.
: Do not bathe your cat or allow them to get wet for at least 24 hours after applying Advantage™ XD. See product label for more information.
: Do not contaminate water, food or feed by storage or disposal of Advantage™ XD.

Storage: Store in original package in a cool dry place inaccessible to children and animals.

Disposal: Call your local solid waste agency or equivalent organization for disposal instructions. Unless otherwise instructed place in trash. Never pour unused product down the drain or on the ground.

Container Handling:

If empty: Non-refillable container. Do not reuse this container. Place in the trash, or offer for recycling if available.

If partly filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.

See product label for more information.

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Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other product names are trademarks of their respective owners.

Always read, understand and follow the label and use directions.