Advantage Multi® for Cats (imidacloprid + moxidectin)

Advantage Multi® is more than just an effective worm treatment for cats. It not only protects your cat from intestinal worms* and heartworm, but it also kills fleas and ear mites — all in one easy, monthly prescription topical.

Protection that’s worth the prescription

  • An icon of a dead flea.
    Fights flea infestations

    Advantage Multi® kills fleas through contact so they don’t have to bite your cat to die.

  • An icon of group of heartworm and intestinal worms.
    Thorough protection against worms

    Advantage Multi® protects your cat from multiple intestinal worms* and heartworm. 

  • An icon of antibiotics within a no symbol.
    No pills required

    The struggle to get your cat to swallow a pill is real. A monthly topical application means less stress for you and your cat.

  • An icon of a calendar with a check mark.
    Heartworm prevention that forgives if you forget**

    Even if you’re a few days late applying that monthly dose, just treat immediately and resume your monthly schedule.

*Treats and controls roundworms and hookworms in cats.
**Per label indications Advantage Multi should be applied monthly

Helps prevent five parasites in one easy dose

Advantage Multi® prevents and treats flea infestations with the active ingredient imidacloprid, which kills fleas through contact so they don’t have to bite your pet to die. It also treats ear mites, which are the No. 1 cause of ear infections in cats.1 Advantage Multi’s other active ingredient, moxidectin for cats, kills intestinal parasites including roundworms and hookworms as well as heartworm. 

See how Advantage Multi® flea, heartworm and intestinal worm protection for cats compares to other preventives. 

†Based on label comparisons.

How to buy Advantage Multi® online

Wondering if you can buy Advantage Multi® for cats or any heartworm prevention for cats without a vet prescription? U.S. Food and Drug Administration (FDA) labeling states that heartworm preventives are to be used by, or on the order of, licensed veterinarians only.  

The good news: It’s easy to buy heartworm meds for cats, including Advantage Multi®, online after you get a prescription from your vet. Most retailers will request your vet’s contact information to verify your prescription. Then, a licensed pharmacist will fill your prescription and ship Advantage Multi® right to your door. 

Ready to give your cat Advantage Multi® prescription parasite protection? 

Watch how to apply Advantage Multi® to your cat. 

How to apply Advantage Multi® for Cats


Remove one dose applicator tube from the package. While holding the tube in an upright position, remove the cap from the tube.


Turn the cap over and push the other end of the cap onto the tip of the tube. Twist the cap to break the seal, and then remove the cap from the tube.


Part the hair on the back of the cat’s neck at the base of the head until the skin is visible.


Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift the tube away from the skin before releasing pressure on the tube.

Ferrets need parasite protection, too.

Advantage Multi® for Cats can also safely be used on ferrets that weigh at least 2 pounds. It's the only FDA-approved product indicated for killing adult fleas, treating flea infestations and preventing heartworm disease in ferrets.‡ Available with a prescription from your ferret's vet, Advantage Multi® provides comprehensive protection against multiple parasites — all in one convenient monthly topical application.

Product Label >
Application & Safety Information >

‡Advantage Multi® for Cats (imidacloprid + moxidectin) (0.4 mL) is indicated for ferrets that weigh at least 2 lbs.

Top questions about Advantage Multi®

Advantage Multi, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. All other trademarks are the property of their respective owners.

Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. Advantage Multi for Cats is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites:

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Cats to use by or on the order of a licensed veterinarian. WARNINGS: Do not use on sick or debilitated cats or ferrets. Do not use on underweight cats (see ADVERSE REACTIONS). Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight. Do not use on ferrets less than 2 lbs. body weight. PRECAUTIONS: Avoid oral ingestion. HUMAN WARNINGS: Children should not come in contact with the application site for 30 minutes after application.