long-lasting Befrena. 6-8 weeks of long lasting itch relief for dogs

befrena starts relieving itch in dogs in 24 hours

Clinic administered injections. no at home daily treament required with befrena

Befrena™: Where Lasting Itch Relief Begins

Befrena offers at least 6 weeks of relief from allergic itch for dogs and begins working in just 24 hours. Befrena has been shown to be effective for the treatment of dogs against allergic dermatitis and canine atopic dermatitis (CAD).

Allergic Itch Relief for Your Dog with Befrena

Long Lasting
At least 6 weeks of itch relief provided to your dog.
Fast Acting
Befrena starts relieving itch in 24 hours.
Convenient
Injections administered in-clinic means no need for at-home daily treatment
Safe
There are no age or weight restrictions for Befrena.

How Befrena Works

Stop the itch signal where it starts

Working in a similar way to the dog's immune system, Befrena targets and neutralizes IL-31, a specific protein involved in sending itch signals to the brain.

The First Step to Relief? A Better Conversation with Your Vet

Addressing allergic itch with an effective treatment like Befrena can provide rapid, long-lasting relief to help your bestie feel their best. The journey starts with a conversation with your veterinarian. Our downloadable brochure and Itch Tracker help you bridge the gap between home and the clinic, giving your vet a precise look at your dog's comfort levels so you can work together on a treatment plan that works.

Get My Itch Tracker

How Befrena is Administered

Befrena is available by prescription only. This injection is administered in-clinic by your veterinarian or a licensed veterinary technician, generally every 6-8 weeks or according to your dog’s individual needs.

Understanding Allergic Itch

Why is my dog itching?

Canine allergic skin disease (atopic dermatitis) is a widespread condition that triggers itching in dogs. Causes range from food and fleas to environmental allergens, with signs that include licking, chewing, rubbing, and scratching.^1,2 Left untreated, these behaviors can damage your dog’s skin, putting them at greater risk for infections leading to hot spots and increased inflammation.^1,2

Frequently Asked Questions About Befrena

: Befrena was proven to relieve itch in the majority of dogs for 6-8 weeks, but your vet may adjust the timing based on your dog’s clinical signs.
: Befrena starts working within 24 hours. By reducing clinical signs related to itching and scratching, other signs you noticed may improve indirectly (e.g., more restful sleep, better overall mood, more playful).
: No downtime is expected after each Befrena injection. In fact, your dog should begin to feel relief from itch within 24 hours. Feel free to walk, play, and cuddle as usual. And monitor your dog's comfort level on the Itch Tracker that you can find on the back page of the Pet Owner Brochure that you may have received during your appointment. If you see signs of itch returning, it's time to visit your veterinarian.
: Monitor your dog's allergic itch closely, as each dog responds differently. Use the Itch Tracker on the back page of the Pet Owner Brochure that you may have received during your appointment. If their itch returns (e.g., frequent scratching, licking, chewing), it's time to visit your veterinarian.
: There are no labeled contraindications for the use of Befrena in dogs with concurrent diseases or taking other medications. It is always recommended to talk to your veterinarian about all the medications your dog is taking.
: Clinical studies showed that Befrena's side effects were comparable to placebo, with dermatitis and bacterial skin infection common to both. The most common side effects include lethargy, diarrhea, vomiting, and injection site reactions.³
: There are several treatments to relieve your dog's allergic dermatitis, each with unique ways of working. Befrena is an injectable medication that specifically targets a dog's response to itch triggers and is given at your veterinary clinic every 6-8 weeks or as needed, providing a long-lasting, highly targeted anti-itch solution for dogs. Know that certain dogs respond more effectively to one treatment option compared to another.
: Yes! Every dog responds differently to medicines, so just because one treatment didn't work, doesn't mean Befrena won't. Consult with your veterinarian on the best treatment option for your dog's itch relief.
: Cost varies by your dog’s weight and your clinic’s pricing.

Always read, understand, and follow the label and use directions.

INDICATIONS: Befrena has been shown to be effective for the treatment of dogs against allergic dermatitis and canine atopic dermatitis (CAD).

For product questions or to report suspected adverse events, call 1-888-545-5973.

1. Collins B. Atopic Dermatitis. Cornell Richard P. Riney Canine Health Center. https://www.vet.cornell.edu/departments-centers-and-institutes/riney-canine-health-center/canine-health-topics/atopic-dermatitis-atopy. Accessed January 15, 2026.

2. Llera R, Hunter T, Ward E. Pruritus: Itching and Scratching in Dogs. VCA Animal Hospitals. https://vcahospitals.com/know-your-pet/pruritus-itching-and-scratching-in-dogs. Accessed January 15, 2026.

3. Elanco Animal Health. Data on File. REF-28722

Befrena™: Where Lasting Itch Relief Begins

Allergic Itch Relief for Your Dog with Befrena

How Befrena Works

Stop the itch signal where it starts

The First Step to Relief? A Better Conversation with Your Vet

How Befrena is Administered

Understanding Allergic Itch

Why is my dog itching?

Frequently Asked Questions About Befrena

How often will my dog need injections?

When does Befrena begin working?

Can my dog return to normal activities after the injection?

What if the itching returns before the next scheduled visit?

Can my dog still receive Befrena while they’re on other medications?

What are the possible side effects?

How does Befrena compare to other itch treatments?

Another similar treatment didn't work for my dog. Is it worth trying Befrena?

How much does Befrena cost?

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