Advantage® II flea treatment for cats

Fight the misery of biting fleas with Advantage® II, a monthly topical flea treatment for cats at least 8 weeks old and 2 lbs. or more. 


To buy Advantage® II, just select your cat’s weight, your preferred number of doses and your favorite retailer below — no prescription required.

How does Advantage® II work on cats?

  • Green drawings of a flea through different life cycles
    Comprehensive protection

    Advantage® II treats and prevents fleas, flea eggs and flea larvae. 

  • An Advantage II topical applicator icon
    Easy to apply

    Just apply Advantage® II once a month to the skin at the base of your cat’s skull* — no hard-to-swallow pills.

  • A green target icon
    Kills through contact

    Unlike oral flea treatments, Advantage® II kills fleas through contact so they don’t have to bite your cat to die.

  • A stopwatch icon outlined by a clockwise arrow showing the product is fast and effective
    Fast and effective

    Advantage® II starts killing fleas on cats within 12 hours, is waterproof after 24 hours and keeps working for 30 days. 


*See product label for complete directions for use.

Ready to get started with Advantage® II for kittens, small cats or large cats?

How to apply Advantage® II for cats

It’s easy to apply Advantage® II to your cat. Just watch this video or see the product label for specific application instructions. 

Flea bites vs. bed bug bites

What’s the difference between fleas and bed bugs? The two tiny, wingless, blood-sucking insects have many similarities, but one key difference is that bed bugs prefer humans, while fleas prefer pets. Even indoor cats can get fleas, so if your cat starts scratching excessively, it’s a good idea to check for fleas and start using a preventive like Advantage® II. 

Protect your cat, house and yard with the Advantage® Family

The Advantage® Family can do more than help you get rid of fleas on cats. We offer a full line of products designed to take out fleas, ticks and more wherever they may be hiding on your feline friend and around your home. If you're ready to show these bloodsuckers who’s boss, it's time to join the Family. 

Top questions about Advantage® II for Cats

Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.