Advantage® II flea treatment for dogs

Fight the misery of biting fleas with Advantage® II, an easy-to-apply monthly flea treatment for puppies and dogs at least 7 weeks old and 3 lbs. or more.


To buy Advantage® II, just select your dog’s weight, your preferred number of doses and your favorite retailer below — no prescription required.

How does Advantage® II topical flea treatment for dogs work?

  • Green drawings of a flea through different life cycles
    Comprehensive protection

    Advantage® II treats and prevents fleas, flea eggs, flea larvae and chewing lice. 

  • An Advantage II topical applicator icon
    Easy to apply

    Just apply Advantage® II once a month directly to the
skin on your dog's back — no hard-to-swallow pills.

  • A green target icon
    Kills through contact

    Unlike oral flea treatments, Advantage® II kills fleas through contact so they don’t have to bite your dog to die.

  • A stopwatch icon outlined by a clockwise arrow showing the product is fast and effective
    Fast and effective

    Advantage® II starts killing fleas within 12 hours, is waterproof after 24 hours and keeps working for 30 days. 

Ready to get started with Advantage® II flea prevention for small, medium, large or extra-large dogs?

How to apply Advantage® II for dogs

It’s easy to apply Advantage® II to your dog. Just watch the video or see the product label for specific application instructions. 

Fleas vs. lice: What’s the difference?

Wondering how to tell the difference between fleas and lice? Both parasites are small, wingless insects that bite and chew the skin, but they have some key differences. Fleas are more mobile and harder to find than lice. Fleas also live longer than lice and can lay thousands more eggs. The good news? Monthly applications of Advantage® II protect dogs from fleas, flea eggs and flea larvae as well as chewing lice.

Protect your dog, house and yard with the Advantage® Family

Fleas aren’t just trying to take a bite out of your canine companion — they could also be hiding out in your home and yard, along with other pests. That’s why the Advantage® Family offers a full line of topicals, chews, shampoos and sprays to help you show these bloodsuckers who’s boss. 

Top questions about Advantage® II for Dogs

Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.