Advantage Multi® for Dogs (imidacloprid + moxidectin)

Advantage Multi® is more than just an effective worm treatment for dogs. It protects your canine companion from fleas and sarcoptic mange as well as heartworm and intestinal worms* — all in one monthly prescription topical that forgives if you forget.**

Protection that’s worth the prescription

  • An icon of group of heartworm and intestinal worms.
    Kills multiple worms

    Protect your dog from parasites including heartworm and intestinal worms.*

  • An icon of a calendar with a check mark.
    Heartworm prevention that forgives if you forget**

    Just treat immediately if you’re a few days late.

  • Flea-tick-heartworm application icon.
    Easy-to-apply topical dose

    Simply apply to your dog’s back according to label directions once a month.

  • An icon of a dead flea.
    Fights flea infestations

    Advantage Multi® kills fleas through contact so they don’t have to bite your dog to die.

*Treats and controls roundworms, whipworms and hookworms in dogs.
**Per label indications Advantage Multi should be applied monthly

Heartworm prevention for dogs that works all month long

Without prevention, heartworm disease can be deadly. Unlike oral heartworm preventives for dogs, the topical moxidectin in Advantage Multi® absorbs into the body and keeps killing worms all month long. Plus, Advantage Multi® forgives if you forget. So even if you’re a few days late applying that monthly dose, just treat immediately and resume your monthly schedule.**

**Per label indications Advantage Multi should be applied monthly

See how Advantage Multi® for Dogs compares to other preventives.†

†Based on label comparisons. 

Helps protect from five parasites in one easy dose

Not every dog flea and heartworm medicine works the same way. Advantage Multi® protects dogs from heartworm and intestinal worms, including hookworms, roundworms and whipworms, at multiple stages. It also prevents and treats flea infestations, killing fleas through contact so they don’t have to bite your pet to die. Advantage Multi® even treats and controls sarcoptic mange, a skin infection caused by parasitic mites that dogs can pick up from other dogs at doggy day cares, dog parks and groomers. 

How to buy Advantage Multi® online

Wondering if you can buy a dog heartworm medicine without a vet prescription? U.S. Food and Drug Administration (FDA) labeling states that dog heartworm preventives are to be used by, or on the order of, licensed veterinarians only.  

The good news: It’s easy to buy heartworm meds for dogs, including Advantage Multi®, online after you get a prescription from your vet. Most retailers will request your vet’s contact information to verify your prescription. Then, a licensed pharmacist will fill your prescription and ship Advantage Multi® right to your door. 

Ready to give your dog Advantage Multi® prescription parasite protection?

Watch how to apply Advantage Multi® to your dog. 

How to apply Advantage Multi® for Dogs


Remove one dose applicator tube from the package. While holding the tube in an upright position, remove the cap from the tube.


Turn the cap over and push the other end of the cap onto the tip of the tube. Twist the cap to break the seal, and then remove the cap from the tube.


Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades.


For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at three or four spots on the top of the backline from the base of the neck to the upper back, in an area inaccessible to licking.

Top questions about Advantage Multi® for Dogs

Advantage Multi, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. All other trademarks are the property of their respective owners. 

Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Advantage Multi for Dogs is indicated for the treatment and control of sarcoptic mange caused by Sarcoptes scabei var. canis. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites:

Important Safety Information
CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions for more information.)
CONTRAINDICATIONS: Do not use this product on cats.