Advantage Multi® for Dogs (imidacloprid + moxidectin)

Your dog can be at risk for heartworms, intestinal worms* and fleas. Protect them from multiple parasites with 5-in-1 Advantage Multi® — the monthly prescription topical that forgives if you forget.

Advantage multi pack shots for dogs and puppies' sizes

Protection that’s worth the prescription

  • An icon of group of heartworm and intestinal worms.
    Kills multiple worms

    Protect your dog from parasites including heartworms and intestinal worms.*

  • An icon of a calendar with a check mark.
    Heartworm prevention that forgives if you forget

    Just treat immediately if you’re a few days late.

  • Flea-tick-heartworm application icon.
    Easy-to-apply topical dose

    Simply apply to your dog’s back according to label directions once a month.

  • An icon of a dead flea.
    Fights flea infestations

    Advantage Multi® kills fleas through contact so they don’t have to bite your dog to die.

*Treats and controls roundworms, whipworms and hookworms in dogs.

An image of a heart with monthly heartworm prevention dosage chart

Heartworm prevention for dogs that works all month long

Without prevention, heartworm disease can be deadly. Unlike oral heartworm preventives for dogs, the topical moxidectin in Advantage Multi® absorbs into the body and keeps killing worms all month long. Plus, Advantage Multi® forgives if you forget. So even if you’re a few days late applying that monthly dose, just treat immediately and resume your monthly schedule. 

See how Advantage Multi® for Dogs compares to other preventives.†

†Based on label comparisons. 

Flea, ear mites, heartworms and intestinal worms' icons with advantage multi topical solution

Prevents five parasites in one easy dose

Advantage Multi® protects against heartworms and intestinal worms at multiple stages, such as hookworms, roundworms and whipworms. It also prevents and treats flea infestations, killing fleas through contact so they don’t have to bite your dog to die. Advantage Multi® even treats and controls sarcoptic mange, a skin infection caused by parasitic mites that dogs can pick up from other dogs at doggy day care, dog parks and groomers.  

Advantage multi pack shots for dog sizes with prescription and dosage chart

How to buy Advantage Multi® online

1. Visit your vet to get a prescription for Advantage Multi®. 

2. Find Advantage Multi® online.

3. Add Advantage Multi® to your cart, and proceed to checkout. 

4. Most retailers will request some details about your pet, along with your vet’s contact information to verify your prescription. (There will also be an option to mail in the prescription.) 

5. A licensed pharmacist will fill your prescription and ship Advantage Multi® right to your door.  

Ready to get your dog prescription parasite prevention with Advantage Multi®?

How to apply Advantage Multi® for Dogs


Remove one dose applicator tube from the package. While holding the tube in an upright position, remove the cap from the tube.


Turn the cap over and push the other end of the cap onto the tip of the tube. Twist the cap to break the seal, and then remove the cap from the tube.


Part the hair on the back of the dog between the shoulder blades until the skin is visible. For dogs weighing 20 lbs. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades.


For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at three or four spots on the top of the backline from the base of the neck to the upper back, in an area inaccessible to licking.

Advantage Multi, Elanco and the diagonal bar are trademarks of Elanco or its affiliates. All other trademarks are the property of their respective owners. 

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions for more information.) CONTRAINDICATIONS: Do not use this product on cats.


Date of review April 2022

© 2023 Elanco or its affiliates