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Compare Advantage Multi® for Dogs (imidacloprid + moxidectin) with other parasite preventives

All dogs need heartworm prevention, but what kind of protection should you give them from other parasites, such as fleas and intestinal worms? Use our comparison charts to explore the differences between Advantage Multi® for Dogs and other preventives.* All products require a veterinarian’s prescription.


*Based on label indications: parasites and life stages.


Advantage Multi® for Dogs† vs. REVOLUTION®

Advantage Multi® for Dogs vs. REVOLUTION® comparison chart

Advantage MultiAdvantage Multi
FORM/DOSE
PREVENTS HEARTWORMS
KILLS HEARTWORM OFFSPRING (MICROFILARIAE)
KILLS FLEAS
KILLS ROUNDWORMS
KILLS HOOKWORMS
KILLS WHIPWORMS
TREATS SARCOPTIC MANGE
TREATS EAR MITES
KILLS AMERICAN DOG TICKS

Advantage Multi® for Dogs† vs. HEARTGARD Plus®‡

Advantage Multi® for Dogs vs. HEARTGARD Plus® comparison chart

Advantage MultiAdvantage Multi
FORM/DOSE
PREVENTS HEARTWORMS
KILLS HEARTWORM OFFSPRING (MICROFILARIAE)
KILLS FLEAS
TREATS SARCOPTIC MANGE
KILLS ROUNDWORMS
KILLS HOOKWORMS
KILLS WHIPWORMS

Advantage Multi® for Dogs† vs. SENTINEL® FLAVOR TABS®§

Advantage Multi® for Dogs vs. SENTINEL® FLAVOR TABS® comparison chart

Advantage MultiAdvantage Multi
FORM/DOSE
PREVENTS HEARTWORMS
KILLS HEARTWORM OFFSPRING (MICROFILARIAE)
KILLS ADULT FLEAS
KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED
PREVENTS FLEA INFESTATIONS
TREATS SARCOPTIC MANGE
KILLS IMMATURE ROUNDWORMS
KILLS ADULT ROUNDWORMS
KILLS IMMATURE HOOKWORMS
KILLS ADULT HOOKWORMS
KILLS WHIPWORMS

Advantage Multi® for Dogs† vs. ProHeart® 6 and ProHeart® 12**

Advantage Multi® for Dogs vs. ProHeart® comparison chart

Advantage Multi Advantage Multi
FORM/DOSE
PREVENTS HEARTWORMS
KILLS HEARTWORM OFFSPRING (MICROFILARIAE)
KILLS FLEAS
TREATS SARCOPTIC MANGE
KILLS IMMATURE ROUNDWORMS
KILLS ADULT ROUNDWORMS
KILLS IMMATURE HOOKWORMS
KILLS ADULT HOOKWORMS
KILLS WHIPWORMS

Advantage Multi® for Dogs† vs. Simparica TRIO™††

Advantage Multi® for Dogs vs. Simparica TRIO™ comparison chart

Advanatge Multi Advanatge Multi
FORM/DOSE
PREVENTS HEARTWORMS
KILLS HEARTWORM OFFSPRING (MICROFILARIAE)
KILLS ADULT FLEAS
KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED
PREVENTS FLEA INFESTATIONS
TREATS SARCOPTIC MANGE
KILLS IMMATURE ROUNDWORMS
KILLS ADULT ROUNDWORMS
KILLS IMMATURE HOOKWORMS
KILLS ADULT HOOKWORMS
KILLS WHIPWORMS
KILLS TICKS

Ready to provide your dog with the multiple benefits of Advantage Multi®?

Advantage Multi, Elanco and the diagonal slash are trademarks of Elanco or its affiliates. All other trademarks are the property of their respective owners.

*Based on label indications: parasites and life stages.

†Advantage Multi® for Dogs is indicated for the treatment of roundworms (T. canis adults, T. canis L4 and T. leonina); hookworms (A. caninum adults, A. caninum immature adults, A. caninum L4, U. stenocephala adults, U. stenocephala immature adults and U. stenocephala L4); and whipworms (Trichuris vulpis). 

‡HEARTGARD Plus® for dogs is indicated for the treatment and control of hookworms (A. caninum, A. braziliense, and U. stenocephala) and roundworms (T. canis and T. leonina). 

§SENTINEL® FLAVOR TABS® are indicated for the control of adult hookworm (A. caninum) and the removal and control of adult roundworm (T. canis and T. leonina) and whipworm (Trichuris vulpis) infections.

**ProHeart® 6 and ProHeart® 12 are indicated for the treatment of existing larval and adult hookworm (A. caninum and U. stenocephala) infections.

††Simparica TRIO™ is indicated for the treatment and control of roundworm (immature adult and adult T. canis and adult T. leonina) and adult hookworm (A. caninum and U. stenocephala) infections. 

CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions for more information.) CONTRAINDICATIONS: Do not use this product on cats.