Compare Advantage Multi® for Dogs (imidacloprid + moxidectin) with other parasite preventives
All dogs need heartworm prevention, but what kind of protection should you give them from other parasites, such as fleas and intestinal worms? Use our comparison charts to explore the differences between Advantage Multi® for Dogs and other preventives.* All products require a veterinarian’s prescription.
*Based on label indications: parasites and life stages.
Advantage Multi® for Dogs† vs. REVOLUTION®
Topical heartworm and flea preventives that treat other parasites differently
Both Advantage Multi® for Dogs and REVOLUTION® are monthly topical treatments that prevent heartworms, kill fleas and treat sarcoptic mange, a skin infection caused by parasitic mites. Your choice may depend on whether your dog is more prone to intestinal worms, ear mites or ticks.
Swipe to explore more differences.
Advantage Multi® for Dogs vs. REVOLUTION® comparison chart
 Advantage Multi | ||
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| KILLS ROUNDWORMS | ||
| KILLS HOOKWORMS | ||
| KILLS WHIPWORMS | ||
| TREATS SARCOPTIC MANGE | ||
| TREATS EAR MITES | ||
| KILLS AMERICAN DOG TICKS |
| Advantage Multi |  Revolution | |
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| KILLS ROUNDWORMS | ||
| KILLS HOOKWORMS | ||
| KILLS WHIPWORMS | ||
| TREATS SARCOPTIC MANGE | ||
| TREATS EAR MITES | ||
| KILLS AMERICAN DOG TICKS |
Advantage Multi® for Dogs† vs. HEARTGARD Plus®‡
Worm treatments with different levels of protection from other parasites
Advantage Multi® for Dogs, a topical treatment, and HEARTGARD Plus®, a chewable tablet, both prevent heartworms and kill two types of intestinal worms: Roundworms and hookworms. But Advantage Multi® for Dogs treats more internal and external parasites.
Swipe to explore more differences
Advantage Multi® for Dogs vs. HEARTGARD Plus® comparison chart
 Advantage Multi | ||
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS ROUNDWORMS | ||
| KILLS HOOKWORMS | ||
| KILLS WHIPWORMS |
| Advantage Multi |  Heartgard | |
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS ROUNDWORMS | ||
| KILLS HOOKWORMS | ||
| KILLS WHIPWORMS |
Advantage Multi® for Dogs† vs. SENTINEL® FLAVOR TABS®§
Similar heartworm preventives that treat fleas differently
Advantage Multi® for Dogs, a topical treatment, and SENTINEL® FLAVOR TABS®, a chewable tablet, both protect against heartworms and intestinal worms. But they treat fleas and other parasites in different ways.
Swipe to explore more differences.
Advantage Multi® for Dogs vs. SENTINEL® FLAVOR TABS® comparison chart
 Advantage Multi | ||
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS ADULT FLEAS | ||
| KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED | ||
| PREVENTS FLEA INFESTATIONS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS |
| Advantage Multi |  Sentinel spectrum | |
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS ADULT FLEAS | ||
| KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED | ||
| PREVENTS FLEA INFESTATIONS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS |
Advantage Multi® for Dogs† vs. ProHeart® 6 and ProHeart® 12**
Heartworm preventives with different dosing schedules
Both Advantage Multi® for Dogs and ProHeart® prevent heartworms, but in different ways: Advantage Multi® is a monthly topical application, while ProHeart® is an injection given once or twice a year at your veterinarian’s office. Although ProHeart® offers less frequent treatments, it treats no external parasites.
Swipe to explore more differences.
Advantage Multi® for Dogs vs. ProHeart® comparison chart
| Advantage Multi | ||
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS |
| Advantage Multi |  Pro Heart | |
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS FLEAS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS |
Advantage Multi® for Dogs† vs. Simparica TRIO™††
Heartworm and flea preventives that treat other parasites differently
Both Advantage Multi® for Dogs, a topical treatment, and Simparica TRIO™, a chewable tablet, prevent heartworms and kill fleas. Your choice may depend on your dog’s lifestyle and whether intestinal worms, ticks or sarcoptic mange pose a greater risk.
Swipe to explore more differences.
Advantage Multi® for Dogs vs. Simparica TRIO™ comparison chart
| Advanatge Multi | ||
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS ADULT FLEAS | ||
| KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED | ||
| PREVENTS FLEA INFESTATIONS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS | ||
| KILLS TICKS |
| Advanatge Multi |  Simparica Trio | |
|---|---|---|
| FORM/DOSE | ||
| PREVENTS HEARTWORMS | ||
| KILLS HEARTWORM OFFSPRING (MICROFILARIAE) | ||
| KILLS ADULT FLEAS | ||
| KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED | ||
| PREVENTS FLEA INFESTATIONS | ||
| TREATS SARCOPTIC MANGE | ||
| KILLS IMMATURE ROUNDWORMS | ||
| KILLS ADULT ROUNDWORMS | ||
| KILLS IMMATURE HOOKWORMS | ||
| KILLS ADULT HOOKWORMS | ||
| KILLS WHIPWORMS | ||
| KILLS TICKS |
Ready to provide your dog with the multiple benefits of Advantage Multi®?
Advantage Multi, Elanco and the diagonal slash are trademarks of Elanco or its affiliates. All other trademarks are the property of their respective owners.
*Based on label indications: parasites and life stages.
†Advantage Multi® for Dogs is indicated for the treatment of roundworms (T. canis adults, T. canis L4 and T. leonina); hookworms (A. caninum adults, A. caninum immature adults, A. caninum L4, U. stenocephala adults, U. stenocephala immature adults and U. stenocephala L4); and whipworms (Trichuris vulpis).
‡HEARTGARD Plus® for dogs is indicated for the treatment and control of hookworms (A. caninum, A. braziliense, and U. stenocephala) and roundworms (T. canis and T. leonina).
§SENTINEL® FLAVOR TABS® are indicated for the control of adult hookworm (A. caninum) and the removal and control of adult roundworm (T. canis and T. leonina) and whipworm (Trichuris vulpis) infections.
**ProHeart® 6 and ProHeart® 12 are indicated for the treatment of existing larval and adult hookworm (A. caninum and U. stenocephala) infections.
††Simparica TRIO™ is indicated for the treatment and control of roundworm (immature adult and adult T. canis and adult T. leonina) and adult hookworm (A. caninum and U. stenocephala) infections.
CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions for more information.) CONTRAINDICATIONS: Do not use this product on cats.
